Phenylethylamine (PEA 2-phenylethylamine (b-phenylethylamine Phenethylamine,) is a trace amino acid. The brain naturally transforms the amino acid L-Phenylalanine to Phenylethylamine (PEA).
PEA isn’t among the top Nootropics stack options due to its effects being so brief-lived. However, some neurohackers love PEA because of it’s stimulantand mood-enhancing properties.
The most well-known promoter of Phenylethylamine is the Dr. Alexander Shulgin and his wife Anna. The Dr. Shulgin published ‘ PiHKAL: An Chemical Love Story’ in the year 1991. PiHKAL stands to mean ” Phenethylamines I Have known and loved”.
Phenylethylamines are a class of Phenethylamine derivatives that contain PEA as the backbone. The derivative compounds are created through the replacement of hydrogen molecules within the structure of the core.
This category comprised of PEA substances includes amphetamines, stimulants, empathogens, psychoactives, appetite suppressants, nasal decongestants, bronchodilators and antidepressants.
One of the more famous PEA derivatives is Methylenedioxymethamphetamine (MDMA or Ecstasy).
The Dr. Shulgin developed, tested and published formulas for 179 compounds that are largely based on PEA’s structure. PEA in his book PiHKAL.
In this review, we examine the way the phenylethylamine (PEA) works in the brain.
- Anxiety & Depression. PEA stimulates TAAR1 as well as TAAR2 receptors, which then hinders the absorption and increases production of ‘feel good neurotransmitters dopamine and serotonin.
- Neuroprotector. Monoamine Oxase blocks the catecholamines such as dopamine and norepinephrine. Dopamine levels decrease and are linked to diseases such as Parkinson’s disease. PEA aids in increasing dopamine as well as norepinephrine levels. Reduces the symptoms of neurodegenerative diseases.
- Attention Deficit Disorder (ADHD). PEA blocks the reuptake of norepinephrine and dopamine, and hinders their transportation. Similar to its mechanism of action espoused through ADHD stimulants medications. Certain have reported that supplementing by using PEA in the form of a nootropic has reduced ADHD symptoms. ADHD.
Phenylethylamine (PEA 2-phenylethylamine (b-phenylethylamine Phenethylamine,)is a trace natural amine that is synthesized by the L-phenylalanine within your brain.
Aromatic amino-acid decarboxylase transforms phenylalanine into the phenylethylamine. It is also the enzyme that transforms phenylalanine to dopamine. It converts it at a rate that is comparable to the production of dopamine.
However, PEA isn’t stored within the neuronal vesicles as dopamine is stored. In contrast, monoamine oxidase-B (MAO-B)quickly degrades PEA.
Despite its brief time-to-effect, PEA as a nootropic appears to be effective in stimulating catecholamine activity through the stimulation of dopamine as well as norepinephrine.
PEA is found naturally in a variety of cacao algae, fungi and bacteria, and clover beans, peas, as well as certain food items like Natto and eggs.
PEA can also be found also in chocolate which is made in the cocao’s roasting and fermentation processes.
PEA is a receptor for C-proteins, TAAR1 and TAAR2 which are receptors that are reserved to traceamine use. The receptors mentioned above are not utilized by other neurotransmitters of major importance, such as norepinephrine or dopamine.
Half-life for PEA used as an Nootropic Supplement is between 5 and 10-minutes. Because it is quickly destroyed by monoamine oxidase B (MAO-B).
A lot of neurohackers elucidate the negative effects of PEA through the use of an monoamine oxidase B inhibitor ( MAOI) such as selegiline (L-deprenyl) or hordenine and Oat Straw.
Phenylethylamine improves brain health and function in a variety of ways. Two of them are notable.
- Phenylethylamine decreases depression. PEA naturally increases the ‘feel good neurotransmitters dopamine as well as serotonin in your brain. Research has shown that depression sufferers, when tested, are less likely to have levels of PEA.
Some even studies suggest that there is a PEA deficit could be the reason for depression in the beginning. In one study, 14 patients suffering from severe depression consume up to 60 mg a each day Phenylethylamine (PEA) together with the dosage of 10 mg selegiline (L-Deprenyl) for up to 50 weeks.
Researchers discovered that “PEA provides long-lasting relief from depression in a large amount of patients, with those who are not responsive to conventional treatment. PEA boosts mood just as quickly as amphetamine, but it does not create tolerance.”
- Phenylethylamine can be described as an mesencephalic enhancer. PEA is regarded as to be a mesencephalic enhancement that is described by ” enhancer-sensitive neurons in the brain that can work for a brief period of time at a high level of activity because of endogenous enhancer chemicals”.
This implies that PEA triggers the release of norepinephrine, dopamine and serotonin from the brain. However, unlike stimulant drugs such as amphetamine that release a surge of neurotransmitters in an uncontrolled way;
PEA does not increases the amount of neurotransmitters released when a nerve is stimulated when it receives an signal from a nearby neuron.
Also, the pattern of the release of neurotransmitters has unchanged. However, when a neuron is able to normally release a neurotransmitter more than the normal amount of it is release.
The result is almost immediate improvements of cognition and the ability to pay attention, be aware and pleasure, libido and a feeling of well-being.
Phenylethylamine is an endogenous (natural or built-in) amphetamine. This is the mechanism that determines the way prescribed ADHD stimulants such as Adderall perform. And the basis for many Schedule 1 drugs like MDMA, LSD, mescaline, and (crystal) methylamphetamine.
Phenylethylamine (PEA) can be metabolized naturally by monoamine oxidase B (MAO-B). As we age MAO-B levels increase and reduce healthy amounts of PEA.
Low PEA levels have been associated with a variety of neurological disorders. It can cause:
- Higher likelihood of ADHD
- Higher likelihood of addiction
- Energy levels decline
- Working memory and mood decline
- Contributing to Parkinson’s Disease
However the presence of high levels of PEA is linked to schizophrenia and migraines.
Phenylethylamine (PEA) quickly crosses the blood-brain barrier when you consume it. You feel the effects immediately.
Activation of TAAR1 receptors stop the uptake and triggers the release of dopamine, norepinephrine and serotonin. It’s like increasing the amount of activity in neurons.
A higher level of neurotransmitters can increase the feeling of pleasure and motivation, enhances the memory and cognitive abilities, and increases the ability to control impulses.
PEA naturally regulates and maintains neuronal activity. It prevents over- or under-stimulation. When it is working according to the plan, PEA and other trace amines can prevent metabolic dysfunction and neurological disorders.
As a neurotransmitter, PEA behaves like it looks and behaves like amphetamines. It also produces the same effects that are normally that are associated with the use of the stimulant. However, unlike amphetamines and because PEA is a natural substance that can be found in the brain, adverse reactions and tolerance are largely avoided.
PEA is a brain part of the brain that is associated with emotion. This results in feelings of joy as well as increased energy and impulse control enhanced creativity, as well as improved sense of smell.
PEA increases libido, social behavior, a feeling of well-being, and improves overall performance.
PEA is being researched and is being used to treat of ADHD and depression, as well as bipolar disorder and cognitive impairment such as the fog of brain and low focus. Furthermore, PEA is promising in treating eating disorders and addictions.
Phenylethylamine is a type of drug which releases dopamine in your brain. This food can be used to create this drug in small amounts but the effects only last for 10 minutes.
Phenylethylamine is a natural chemical that is responsible for pleasurable feelings. It is also responsible for the “love drug” effect that people experience when they are in love with someone.
Phenylethylamine is found in chocolate, strawberries, bananas, avocados, red wine and green tea. With these foods you can prepare delicious meals that make you happy!
Phenylethylamine is a natural chemical that causes excitement and elation.
Phenylethylamine is a natural chemical found in the human body. It causes an “adrenaline kick” or excitement and elation.
Phenylethlamine in Chocolate
The foods that contain phenylethylamine are usually spicy, salty or contain chocolate.
PEA can be quickly degraded by monoamine oxidase B (MAO) so unless you combine PEA with an MAO inhibitor do not expect its effects to last for long. The majority of people experience peak energy within 15 minutes, and then lasting energy for 30 minutes. up to an hour.
If you’re ADHD or ADD You should notice improvements in your mood and attention span concentration as well as mental clarity. It’s not quite the same result that you’d experience from Adderall but with the added benefit of a greater social connection.
Neurohackers recommend using the MAOI (inhibitor) supplement 15 minutes prior to the PEA dose. The effects will last for about two hours. There’s not a crash as that you would normally get from an stimulant. It’s just a general feeling of wellbeing after it has worn off.
A few have said that PEA has helped to break off the addiction to the drug Phenibut as well as caffeine without experiencing withdrawal.
As a pre-workout aid, PEA provides a more intensive and focused exercise.
Neurohackers who are older seem to experience greater benefit from PEA. It is likely because the monoamine oxidase levels are higher than dopamine as older you become. Furthermore, using PEA particularly with a MAOI aids in restoring dopamine and other neurotransmitters which are commonly diminished as you age.
PEA is an excellent nootropic to study as you will experience less stress, fewer anxiety attacks, and less anxiety. Plus, you will experience more positive mood, it’s more focused and have more energy.
Phenylethylamine Weight Loss
Certain people report that their cravings for food decrease and it’s much easier to lose weight.
Phenylethylamine Clinical Research
Phenylethylamine as an Antidepressant
Depression ranks as the 2 2nd most common reason for disability in the ages of 15-44. In 2030, it is predicted that by 2030, the World Health Organization predicts depression to be the most significant reason for disability in the world.
Selective serotonin Reuptake inhibitors (SSRI) are the most commonly prescribed antidepressants worldwide. SSRIs are effective by blocking the serotonin transporter , and thereby preventing the process of reuptake of serotonin. This results in an increase in serotonin levels in synapses.
However, the SSRIs take a long time to work. They also come with a myriad of adverse negative effects. Phenylethylamine (PEA) may be an alternative to SSRIs.
A study conducted in 2008 revealed that PEA affects serotonin transporters through interactions with receptors for TAAR. The increase in serotonin levels is due to the inhibition of their reuptake, just like the prescription SSRIs.
The study suggests that PEA could be a better treatment for depression as compared to SSRIs.
Diagnosis of ADHD is traditionally been determined by analyzing symptoms. However, the measurement of PEA levels has now been suggested as a biomarker to diagnose ADHD.
The discovery of a connection with PEA concentrations and ADHD has enthused researchers. It is because it could improve levels of confidence in ADHD diagnosis. It will also reduce the risk of misdiagnosis and over-medication.
One study found that ADHD children treated with the drug methylphenidate (Ritalin) showed significantly higher PEA levels in the presence of the drug methylphenidate.
PEA is a binding agent for the TAAR1 receptor, which modifies the monoamine transporter function. It also causes the reduction of the reuptake process of serotonin, dopamine, and norepinephrine. This increases the amount of these neurotransmitters within synapses between neurons.
The increase in synaptic concentrations of dopamine is achieved through blocking directly the transporter of dopamine. This is the way that drugs such as the methylphenidate help to increase dopamine levels.
If you’re ADHD and you crave chocolate It’s probably due to the fact that the cocao is a source of PEA.
Certain naturopaths are starting to prescribe PEA in lieu of stimulants such as amphetamines and the methylphenidate for treating ADHD.
Phenylethylamine (PEA) The recommended dosage for cognitive benefits is 500 mg, up to 3 times per day.
PEA has an estimated half-life of 5 to 10-minutes. However, PEA’s effects PEA can be prolonged by making use of a MAO-B inhibitor.
If you decide to use an effective MAOI such as selegiline (l-deprenyl) ensure that you limit the dosage to a minimum (i.e. 2.5 mg) or you’re at risk of reducing MAO-A’s effectiveness. More details on”the ” cheese effect” in the next section.
Doing more than is the recommended amount is not a good option because you’ll probably be irritable, feel anxious and possibly even suffer from headaches, experience nausea, and likely increase your heart rate to alarming levels.
Phenylethylamine Side Effects
“Cheese effect“: Phenylethylamine (PEA) is processed through an enzyme called MAO-B. When Monoamine Oxase (MAO) is blocked through eating cheese, or any other medication or natural MAO inhibitor (MAOI) in combination, it could result in a risky increase of blood pressure.
Research has shown the fact that the selective MAO-B inhibitory is not responsible for the cheese-like effect. The cheese effect is not a result of selective MAO-B inhibition.
Some examples of MAO-B inhibitors that are selective include selegiline at low doses (L-deprenyl) and hordenine. Oat Straw, Glycyrrhiza uralensis (Chinese extract of licorice), Phellondendron amurense (Amur cork tree bark), Ferula assafoetida extract (resin), as well as Psoralea corylifolia (Bu Gu Zhi). [xx*
Do not take Phenylethylamine (PEA) if you are taking an approved MAOI such as Marplan, Nardil, Azilect or Parnate or have taken one within the last 14 days.
Don’t use PEA If you suffer from Phenylketonuria (PKU).
A lot of PEA could cause irritability, nausea, increased the heartbeat, and jitteriness, and can be very dangerous.
Keep in mind that Phenylethylamine (PEA) is an endogenous (natural) amphetamine. If used in a reckless manner, it can cause the same harmful adverse effects as other substances in the amphetamine class of compounds.
Where to buy Phenylethylamine
Phenylethylamine (PEA) is available in tablets, capsules, and also as a bulk powder.
Do not make the error of purchasing Phenylalanine in place of Phenylethylamine (PEA). It’s not the same thing. It’s easy to overlook in the search on the internet for this nootropic.