Piracetam (2-oxo-1-pyrrolidine-acetamide, Nootropil) is a water-soluble ampakine nootropic in the racetam-class of compounds. Piracetam was synthesized for the first time by Dr. Corneliu Giurgea, a Belgian pharmacist firm UCB Pharma in the 1964.
Piracetam is regarded as the first nootropic that has been created. A cyclic derivative of GABA, Piracetam was initially designed to be a calming form of medication for motion sickness. However, despite its relationship with GABA Piracetam did not exhibit any of the behaviors that was correlated with the tranquilizing nerve transmitter. It is also not able to directly affect GABA receptors.
Giurgea discovered that Piracetam could boost cognitive function regardless of health individuals. The company introduced this drug as ‘Nootropil within Europe in the 1970’s early. The popularity of Nootropil quickly allowed UCB Pharma to expand its operations, which resulted in the development of many new pharmaceutical products. The Dr. Giurgea coined the term “nootropic” to refer to the cognition-enhancing compounds.
Nootropic is derived from the Greek words meaning “mind” (noos) as well as “towards” (tropein). Piracetam is available as a prescribed drug ( Nootropil and Lucetam) in Europe. It is also sold in South America, Piracetam is available under the brand name Noostan (Argentina), Breinox (Venezuela and Ecuador) and Nootropil (Mexico). Piracetam is also sold under the names Lucetam, Oikamid, Smart, Geratam, Biotropil, Neurobasal, Stimulan and Nocetan across the globe. The United States, Piracetam is available in the United States as an OTC supplement under the names Piracetam as well as Nootropil.
A myriad of racetam derivatives have been created based on Piracetam. Racetams, like all synthetic compounds have the same nucleus of pyrrolidone. Piracetam affects AMPA receptors and enhances the activity of Acetylcholine within the brain. A popular racetam in those in the community of nootropics. Neurohackers utilize Piracetam to improve the memory as well as the ability to learn.. If you’re planning to begin exploring racetams I suggest that you do so during National Lab Day is to begin with Piracetam. Because it’s effective well, it’s secure and less expensive than the other racetams in the racetam family. Piracetam helps:
- inflammation: Piracetam is a powerful analgesic (anti-pain). The analgesic effects are related to the inhibition of inflammatory markers such as the IL-1b. and the prevention of decreased glutathione ferric reducing capability as well as free radical elimination
- neurotransmitters: Piracetam potentiates the flow of, and enhances the effects of Acetylcholine (ACh) within the brain. Studies have demonstrated that it can significantly enhance memory and learning.
- The Cerebral blood flow: Piracetam improves blood flow to the brain. A better flow of blood provides more nutrients and oxygen to brain cells, enhancing the ability to focus, memory, and cognition.
Piracetam (2-oxo-1-pyrrolidine-acetamide, Nootropil) was the first in the racetam-family of nootropic compounds. It is a non-water-soluble ampakine nootropic. AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain. Piracetam It was developed by a colleague of the famous Russian scientist Ivan Pavlov, Dr. Corneliu Giurgea was the first to synthesize Piracetam in the Belgian pharmaceutical company UCB Pharma in the 1964. After the discovery of Piracetam numerous nootropics have been developed within the racetam class of substances.
They all share an nucleus of pyrrolidone at the core. Piracetam is an cyclic derivative of GABA.. However it doesn’t alter GABA receptors within the brain. In fact, Piracetam was found to regulate AMPA as well as NMDA receptors, and enhance the performance of the neurotransmitter Acetylcholine (ACh). AMPA as well as NMDA receptors, along with Acetylcholine is associated with the development of learning as well as memories. When Piracetam is combined with an Choline supplement, its effects are more prominent. Researchers have demonstrated in a multitude of studies in clinical trials that piracetam greatly improves memory and learning. Piracetam can also increase the flow of cerebral blood.
Blood supplies glucose and oxygen required for cell metabolism and also helps in the elimination of cell waste. Vital for the highly-optimized brain. Piracetam is available as a prescription medication in many nations around the globe. The United States, Piracetam is available in the form of an unregulated OTC study drug.
Piracetam Dosage Guide
Piracetam improves brain health and function in a variety of ways. Two of them are notable.
- Piracetam affects AMPA as well as NMDA receptors in the brain. It also improves the flow of Acetylcholine (ACh) and sensitivity and the density of ACh receptors.
This German study, conducted using mice in the lab showed that Piracetam increased NMDA receptors. It also normalized the way these receptors functioned in conjunction with L-Glutamate like that of healthy brains. Deficits in the levels of NMDA receptors may represent one of the causes of action that underlie the decline in cognitive function that occurs with age.
The researchers concluded that Piracetam demonstrated cognition-enhancing properties. The effect of this of NMDA receptor sites is directly connected to our desire to use Piracetam to enhance Long-Term Potentiation as well as the enhancement for the long-term memory development. Neuroplasticity depends on the activation of NMDA receptors. This neuroplasticity is at the core of memory creation. The reviews of Piracetam, a drug that neurohackers use frequently mention the reemergence of memories that were lost for a long time. Another evidence of the effectiveness of using Piracetam to aid in memory and learning.
- Piracetam boosts the flow of cerebral blood. Numerous studies have demonstrated how Piracetam can positively influence the flow of blood in the brain. The flow of blood in the brain is crucial to the brain’s highly efficient. Blood supplies glucose and oxygen required for cell metabolism and assists in the elimination of the cellular debris.
Strokes may be caused by the interruption of cerebral blood flow. The brain is deprived of glucose and oxygen. The double-blind, placebo-controlled research was conducted on 24 patients suffering from stroke. One group was given 2,400 mg of Piracetam two times every day, while the other group received was given a placebo.
Prior to treatment the two groups performed similarly in their performance on the language task. The study revealed that Piracetam helped in the recovery of many language functions. This effect was attributed to increased blood flow to brain regions that are related to language. The group that was a placebo showed minimal improvement in areas related to the language.
As we age the brain’s metabolism and chemistry change. It seems that these changes are impacting younger and younger individuals.
- Recall Reaction time, learning capacity decreases
- ATP energy levels decline Density of AMPA as well as NMDA receptors decreases.
- Acetylcholine levels decline Cerebral blood flow declines
These changes are all the main causes of cognitive decline. The first signs of these changes are evident in slow decision-making, learning difficulties or recalling basic things such as an important appointment. Even if you’re not worried about age-related signs Piracetam may be able to aid.
Piracetam aids in increasing the flow of blood to the brain, increases the levels of oxygen, increases the use of glucose in brain cells, and helps maintain the brain cells mitochondria and ATP and ATP.
Piracetam can also be a powerful stimulator of AMPA sensitive glutamate receptors in neurons. It enhances the number of binding sites that are specific to AMPA within neurons synapses.
Glutamate can be described as the main excitatory neurotransmitter found in the brain. The glutamate activity of Piracetam influences the ability to focus, alertness as well as memory and learning. One of the reasons that neurohackers regularly affirm that Piracetam enhances memory and mental performance. Piracetam boosts the uptake of high-affinity choline (HACU) which is the process that takes place in the nerve endings of cholinergic nerves. It also facilitates the acetylcholine (ACh) formation.
The stimulation of ACh by piracetam has an impressive impact on memory and learning. Piracetam can also increase the density of choline receptors in the brain’s frontal cortex. The area of your brain used for working memory and decision-making.
The ATP energy is vital for the survival of your brain. Brain cells have to produce the majority of ATP by consuming oxygen and glucose. The brain’s energy metabolism of carbohydrate is dependent upon the flow of cerebral blood, oxygen uptake and glucose.
Piracetam increases the utilization of glucose and also increases ATP production required to fuel brain cell mitochondria. And Piracetam is a drug that has analgesic (anti-pain) advantages. The anti-pain effect is linked with the Piracetam’s anti-inflammatory properties.
Inflammation can trigger pain and research has shown that Piracetam has a profound impact on pain. Piracetam increases acetylcholine, so it is recommended to add a source of choline. Consider Alpha GPC or CDP-Choline which contain Piracetam. Give your brain all the choline it requires.
Piracetam 800mg Uses
The majority of neurohackers experience a significant improvement from Piracetam within two weeks. Take into consideration that Piracetam affects the brain’s chemical. This change is not likely to take place in a short time. The brain requires time to get used to the change in the acetylcholine (ACh) concentrations and the way it utilizes it. The increased cerebral blood flow takes some time to increase the levels of nutrients and oxygen.
Also, for your neurons to react. The mileage you get could differ according to the neurochemical composition of your brain. Many recommend starting with an attack dose for the first 3 days. A 3,000 mg “attack dose’ of Piracetam for instance to begin with theoretically helps to get more of the supplement into your system straight immediately. It will take less time to build up before you begin experiencing the effects. Then, you can lower to a minimum dose and increase the dosage until you have found your personal ideal dosage.
When you start to feel how you feel after taking Piracetam you’ll likely experience an increase in increase in mood and less anxiety around social situations and increased creativity, as well as improved speaking fluency and improved memory. Piracetam can increase the brain’s ability to use Acetylcholine. Therefore, you’ll likely discover that adding a source of choline (Alpha GPC or CDP-Choline) to your Piracetam stack can help.
Piracetam Side Effects
There is plenty of evidence to support Piracetam improves memory in humans and animals who suffer from various kinds of cognitive impairment in humans and animals. Be aware that the majority of the research that is available for nootropics has been conducted with patients who are sick and trying to recover. The ROI of research conducted at universities and institutions is derived from the treatment of diseases.
It is not about helping everyday biohackers, like us, to gain an edge at school or at work. However, we can extrapolate the results of these studies to discover whether and how something like Piracetam helps our cognition and memory. Every now and then, someone takes some time and conduct such an investigation on healthy individuals. Similar to this study conducted with healthy, normal volunteers. Researchers provided this healthy group of participants four capsules of 400 mg of Piracetam three times a day (4,800 mg in total) over 14 consecutive days. The effects on memory were not noticed after 7 days of the study. However, within 14 days, verbal learning was significantly improved.
Piracetam Improves Cognition
Researchers from Belgium (where Piracetam originated) performed an study of 19 placebo-controlled, double-blind studies conducted on patients with cognitive impairment or dementia and who were taking Piracetam. This meta-analysis showed the differences between those who took Piracetam or an alternative. The final result of this study provided convincing evidence of the effectiveness of Piracetam in a variety of groups of cognitively impaired people.
A number of studies and user reviews have proven that Piracetam dosage can make a difference. In contrast to other nootropics that start with a lower dosage and gradually increase and up, with Piracetam starting with a higher recommended dosage. The study conducted in Germany using 78 patients who were elderly found significant differences in the improvement of cognition when taking Piracetam with 1,600 mg three times daily. The study found not a difference between cognitive performance when patients received 800 mg three times daily. Dosage is important when taking Piracetam.
Piracetam Enhances ATP Production
Piracetam is utilized all over all over the world to treat cognitive impairments due to brain injury, aging as well as dementia and Alzheimer’s Disease. Numerous studies have shown that Piracetam improves the production of ATP, mitochondrial membranes and neurite growth in neurons.
In this study, researchers examined how Piracetam in relation to mitochondrial function. Brain cells from humans were treated using Piracetam in normal conditions as well as under conditions that mimic the aging process and damage caused through ROS ( reactive oxygen species). Also, with cells that represent the early stage of Alzheimer’s Disease. The Alzheimer’s disease-related cells had impaired mitochondrial function under the conditions of baseline. Piracetam could reverse the cells’ mitochondrial dysfunction and restore mitochondrial function to normal. Researchers have demonstrated that Piracetam can restore mitochondria in people suffering from mild Alzheimer’s disease and restore the function of cells back in a regular.
Dosage of Piracetam that is recommended
The recommended Piracetam dose is 1600 mg three times daily. A single Piracetam dosage in the early morning and one in the afternoon, and another in the afternoon. It is likely that you will want to begin with an ‘attack dose’ when first beginning using Piracetam.