Nootropics

Phenylalanine is one of the very bio-active important amino acid. The body naturally converts L-Phenylalanine to the amino acid L-Tyrosine, which is then transformed into L-DOPA. The decarboxylation process of L-DOPA leads to the synthesis of brain neurotransmitter dopamine.

Once converted into dopamine, the enzyme dopamine-beta-hydroxylase converts dopamine into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). The triad of neurotransmitters is collectively known as ” catecholamines”. As an Nootropic product, one can discover a variety of types of Phenylalanine available. L-Phenylalanine is the most natural form that is found in proteins. D-Phenylalanine is an exact mirror image of L-Phenylalanine which is produced in the laboratory. It is also known as the DL-Phenylalanine can be described as a mixture of both types.

L-Phenylalanine is an efficient nootropic to boost cognition function due to its ability to boost the production of norepinephrine as well as dopamine production. This results in improved concentration, motivation as well as functioning memory. D-Phenylalanine (but not L-Phenylalanine) is utilized to treat chronic pain , but the research conducted on this topic is a bit sporadic. L-Phenylalanine can also increase T3 and 4 production. T3 (triiodothyronine) and T4 (thyroxine) which are essential to maintain general physical and cognitive health. Phenylalanine assists:

• Cognitive Stress. L-Phenylalanine is a component of the catecholamine-t consisting of the neurotransmitters dopamine, norepinephrine and epinephrine. Stressors that cause sleep deprivation or extreme such as cold and heat can reduce catecholamine levels. L-Phenylalanine replenishes them and helps maintain optimal cognition.
• Neurotransmitters. Phenylalanine is the essential precursor for dopamine, norepinephrine and epinephrine. When your levels of dopamine increase it makes you more able to concentrate and manage your thoughts, and remain productive.
• Attention Deficit Disorder (ADHD). L-Phenylalanine is a good treatment for those suffering from ADHD symptoms. L-Phenylalanine can work in conjunction with other pharmaceutical medications like Ritalin as well as Adderall by increasing the dopamine levels in the extracellular space. Making these drugs more efficient. As well as reducing side effects such as crashes after the drug is worn off.

What is Phenylalanine Used For?

L-Phenylalanine is an essential amino acid you can get through food or supplements. The enzyme Phenylalanine Hydroxylaseconverts Phenylalanine within your body to an amino acid Lyrosine.

The amino acid L-Tyrosine is  Phenylalanine Phenylalanine can be found in proteins-rich foods such as soybeans, cheese and nuts, seeds Lamb, beef chicken, pork eggs, fish dairy, beans as well as whole grain. Aspartame, an artificial sweetener, also is a source of Phenylalanine. The brain converts L-Tyrosine into L-DOPA, which produces dopamine, a neurotransmitter.

Dopamine that is not used up is transformed into neurons that produce the norepinephrine (noradrenaline) as well as Epinephrine (adrenaline). The triad of neurotransmitters is collectively known as ” catecholamines”.

A lot of neurohackers favor the L-Phenylalanine in comparison to others catecholamine precursors since it enhances the production of neurotransmitters without directly increasing the levels of neurotransmitters. This is the most important part since a sweeping increase in neurotransmitters all over the place can cause problems as well as the development of tolerance. This could negate the reason of using the nootropic in the first place. For instance, insufficient epinephrine could affect cognitive function. In addition, too much norepinephrine may reduce attention, processing speed as well as the executive functions.

L-Phenylalanine Vs. D-Phenylalanine: What’s the difference?

L-Phenylalanine is an amino acid that is essential, that is why you should get it through food. It can also be taken as an added supplement. The body is unable to synthesize Phenylalanine by itself.  L-Phenylalanine (LPA) is transformed to the amino acid Lyrosine within your liver. When L-Tyrosine crosses through the brain-blood barrier and enters the blood-brain barrier, it transforms into L-DOPA. It is then transformed into neurotransmitters dopamine, norepinephrine (noradrenaline) and epinephrine (adrenaline).

D-Phenylalanine (DPA) is a synthetic form of, and a mirror image of, L-Phenylalanine that was created in the laboratory. DPA has a distinct mechanism of action within the body as compared to LPA. D-Phenylalanine (DPA) reduces the activity on the enzymes carboxypeptidase A or endorphinase and the enzyme enkephalinase. These enzymes degrade endorphins. The slowing of these enzymes that decrease endorphins could aid in reducing the pain. The DL-Phenylalanine combination is a 50/50 mix of D-Phenylalanine and L-Phenylalanine. Combining the two in theory , you can have the benefit of an antidepressant as well as a pain reliever.

L-Phenylalanine Supplement Benefits for the Brain?

L-Phenylalanine improves brain health and function in a variety of ways. Two of them are notable.

1. L- Phenylalanine decreases depression. L-Phenylalanine converts into L-Tyrosine, which transforms into L-DOPA within the brain. L-DOPA then is used to create the feel-good dopamine, a neurotransmitter. Therefore depression could be due to not receiving enough of the amino acid (L-Phenylalanine) in the chain of events required to make dopamine.

In a study conducted in Germany 20 patients suffering from depression received between 75 and 200 mg each day of DL-Phenylalanine over 20 days. After the study, 12 depressed patients were released without further treatment. Four of them had an improvement in their depression symptoms. Four patients did not show any reaction.

1. L-Phenylalanine increases neurotransmitters. L-Phenylalanine transforms into L-Tyrosine after being it is taken as an supplement. Then it transforms into dopamine, a neurotransmitter. Dopamine controls the movement of your body. It is essential to attention, memory and problem solving.

Dopamine that is not used can transform into neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Norepinephrine is essential in regulating emotions, attention sleep, dreaming, and learning. Epinephrine drives your ‘flight-or-flight’ response. This is what triggers your response to danger in emergency situations or when you’re in stressful situations or situations.

The balance of neurotransmitters in the brain is essential to an well-functioning, healthy brain. This is why many neurohackers opt for L-Phenylalanine as a way to enable the body to produce the neurotransmitters it requires. Instead of creating imbalance by stimulating one neurotransmitter over the other. A study conducted in Venezuela focused on ADHD as well as autism, as well as the effects of amino acids in these neuropsychiatric disorders. 40 autism-related subjects and 11 people with ADHD as well as the healthy 41 subjects enrolled in this study. Researchers found that people who suffer from ADHD were suffering from decreased Phenylalanine and an increase in Glycine, which affected their inhibitory neurotransmission system. Insufficient Phenylalanine and a higher level of lysine were found in people with autism.

Another study conducted at Ohio State University looked at amino acids in 28 ADHD patients. The study found that all patients who suffered from ADHD were significantly lower in levels of the amino acids phenylalanine, tyrosine, histidine, tryptophan and isoleucine. The study concluded that each patient suffered from a common deficiency in the transport of amino acids and absorption, and absorption.

As we age our body and brain change in chemistry and energy metabolism.  Dopaminergic neurons are damaged or die.

• Neurotransmitter levels decline
• Thyroid hormones decline
• Stress levels increase
• The decline in mood and working memory

These changes are usually blamed on the process of aging. However, they could also be the result of lifestyle and dietary choices. If not addressed, they can cause neurodegenerative illnesses such as Parkinson’s disease, a decline in the quality of life, and depression.

L-Phenylalanine benefits

L-Phenylalanine may increase levels of neurotransmitters like dopamine, norepinephrine , and epineph. It can also help a slow thyroid to produce higher levels of T4 as well as T3. L-Phenylalanine is a stimulant for cognition , particularly in stressful situations. It aids in improving decision-making flow state, the ability to think creatively, as well as cognitive flexibility and working memory.

L-Phenylalanine is converted into L-Tyrosine, which transforms into L-DOPA in order to create dopamine. L-DOPA also helps create melanin in the body. This process aids in the elimination from neurotoxic chemicals known as quinones. It also chelates heavy metals such as mercury and lead that can build up and cause damage to neurons.

The dopamine not utilized by your brain can be used to create norepinephrine (noradrenaline) which is essential for attention, emotions sleep, dreaming, and learning. L-Phenylalanine could be a powerful nootropic when combined with ADHD/ADD medications like Ritalin and Adderall. It assists in the supply of extracellular dopamine that is needed to boost the efficacy of stimulants to increase the absorption of dopamine within your brain.

L-Phenylalanine High?

Remember that L-Phenylalanine can be an intermediate to catecholamines . So if you’re not ‘low’ on dopamine , norepinephrine or epinephrine You may not feel you’re not feeling anything. Many neurohackers have reported a boost in mood, improved concentration, focus, more energy levels, and a general feeling of wellbeing.

L-Phenylalanine may help you adjust the level of motivation. It may help reduce anxiety levels, particularly social anxiety. L-Phenylalanine supplementation can lower blood pressure when it is elevated due to an environment or stressful event. Do it prior to the event that is stressful if you are able to.

L-Phenylalanine assists in buffering adverse effects from stimulants such as amphetamines or caffeine. It can enhance and prolong effect of Ritalin or Adderall and also reduces the risk of crash. If you’re an athlete or manual work You’ll discover that taking L-Phenylalanine prior to an exercise or job will leave you feeling fantastic afterward.

It can help reduce some of the negative effects of stress that is caused by stressors that are short-term in nature. L-Phenylalanine aids your body to produce L-Tyrosine, which is needed to make melanin. As a result, you might be able to achieve a tan on the beach.

L-Phenylalanine Dosage

L-Phenylalanine Depression

A number of studies have examined the use of Phenylalanine to treat depression. One study published in the journal Arzneimittel-Forschung looked at using DL-Phenylalanine in a small group of patients who failed to respond to popular antidepressants like MAOIs. In this study researchers collaborated with 23 patients who were diagnosed with depression who were not responding to antidepressants that are commonly prescribed. They received the equivalent of 50 to 100 milligrams of Phenylalanine every day over a period of 15 days.

Researchers discovered the Phenylalanine significantly improved the mood for 17 of the patients. In just 13 days after the trial lasting 15 days. Another study published in The Journal of Neural Transmission examined DL-Phenylalanine usage with 20 patients suffering from depression.

The participants were given 75-200 mg/day of DL-phenylalanine over a period of 20 days. The study revealed that 8 patients fully were able to recover from depression. Another 4 also saw a marked improvement in their mood. Four patients also experienced mild to moderate improvement, and 4 others did not react to treatments. This study demonstrates the fact that Phenylalanine is a powerful antidepressant effects. It is also effective in the vast majority patients who suffer from depressive symptoms.

Phenylalanine for ADHD

Phenylalanine to treat ADHD appears at first glance to be an effective solution to ADHD symptoms. It’s a precursor of the neurotransmitter dopamine that is targeted by stimulants such as Ritalin as well as Adderall. However, the limited clinical data tell an entirely different story regarding its the practical application. In this study, which was a double-blind crossover 19 patients suffering from ADD were treated with the DL-phenylalanine or a placebo for two weeks.

Thirteen of these ADD patients saw a substantial improvement of ADD symptoms when compared to placebo. Patients also noticed an improvement in their mood. However, the patients who responded with DL-Phenylalanine did not experience any positive effects within three months. It’s also interesting to note that a subsequent study of ADHD patients who were treated with L-phenylalanine (not DL-Phenylalanine) did not show any clinical benefits. A different study from 1987 treated 11 hyperactive males for two weeks with D-Phenylalanine for two weeks.

There was no improvement or decline of the behavior. There is a current theory that suggests there are a variety of different kinds of ADD and ADHD. The symptoms result from malfunctions in various parts of the brain based on the type of ADHD. It is true that that some suffering from ADHD might be benefited from supplements their diet with Phenylalanine. It is true that DL-Phenylalanine could be the most effective alternative. Test it out to see whether it does the trick for you.

L-Phenylalanine is a recommended Dosage

The recommended dosage of L-Phenylalanine for cognitive benefits is 500 mg, up to 3 times per day. It is possible that your body reacts differently to lower doses. Even more so if you’re stacking it with stimulants such as ADHD medication. Pay attention to your body and observe what you feel and react to.

Because L-Phenylalanine is an amino acid to ensure optimal absorption, and therefore in no way competing with the other amino acids. you should take it at least one hour prior to eating. L-Phenylalanine is most effective when taken on an empty stomach.

Take L-Phenylalanine along together with Vitamin B6 and Vitamin C to increase absorption. Also, give your body the nutrients it requires to make the neurotransmitters norepinephrine, dopamine and epinephrine. L-Phenylalanine is required together as L-Tyrosine to produce CoQ10. CoQ10 required to power the brain’s mitochondria.

DL-Phenylalanine Side Effects

L-Phenylalanine rapidly transforms into the amino acid non-essential L-Tyrosine after taking it. It is therefore considered to be extremely safe and non-toxic. The majority of neurohackers do not have negative side effects. Important Warning People suffering from Phenylketonuria (PKU), and women who are nursing or pregnant and breastfeeding should not consume the phenylalanine supplement.

PKU is an inheritable condition in which excess phenylalanine may accumulate within the body. Aspartame, which is found in artificial sweeteners like NutraSweet is a major source of the chemical phenylalanine. People suffering from PKU shouldn’t use aspartame. If you are pregnant, consult your physician about the use of the artificial sweetener. In higher doses, there are reports of stomach problems and migraines. Experts believe that L-Phenylalanine can be harmful in doses that exceed 5000 mg. Higher doses will provide you with no additional advantage.

If you have tried the prescribed doses of L-Phenylalanine but don’t notice any benefits the nootropic might not be the right choice for you. It is possible to consider the L-Tyrosine as well as NALT instead. L-Phenylalanine may boost your thyroid hormones. If you’re hyperthyroid, it is not recommended to take L-Phenylalanine.

Phenylalanine Dangers

If are taking MAO inhibitors (MAOI’s) like selegiline Azilect, Marplan, or Nardil, you shouldn’t take L-Phenylalanine. MAOI’s affect the brain and alter neurotransmitters. Therefore, taking L-Phenylalanine with MAOI’s can upset the balance between neurotransmitters required to maintain the best brain health and cognition. When combined with MAOI’s, L-Phenylalanine can cause a significant rise in blood pressure that could result in stroke or heart attack. Other side effects that may be associated with unusually high doses of phenylalani.

Phenylalanine Foods

Phenylalanine is an essential amino acid that is widely found in different kinds of food. However, certain foods are rich in this nutrient and are the best sources of it. Here are some foods with high phenylalanine content that you can eat on a daily basis.

1. Chocolate
2. Nuts
3. Soybeans
4. Almonds
5.  Wheat germ
6. Cashews

Phenylalanine food list is not extensive, but it is still necessary to have the knowledge of these foods to prevent seizures.

A list of phenylalanine foods includes: beef, chicken, eggs, pork, fish, lamb and peanuts. The foods that contain phenylalanines are those that come from animal proteins. The downside to this list is that it only has a few examples of the foods that contain phenylalanines.

Phenylalanine is an amino acid that plays a role in the production of the neurotransmitters dopamine, adrenaline, and noradrenaline. It is also an essential amino acid which means that it cannot be manufactured in the body and needs to be obtained from food.

Phenylalanine sources include meats, dairy products, soybeans, lentils, wheat germ, bran cereal (oatmeal), soy flour (tempeh), wheat flour (pasta), soy protein powders.

Phenylalanine deficient foods include white breads or pasta made with enriched white flour because these are enriched with synthetic phenylalanine substitutes.

Phenylalanine in Drinks

Phenylalanine is an amino acid that is found in many drinks. This amino acid can cause health risks to some people, so it is important to know the amount of phenylalanine in your drink.

Various drinks have different levels of phenylalanine, which means that the drink’s name will not always be a good indicator of whether or not it contains this amino acid.

It might be worth looking at the ingredients list for your drink to see if it contains any sources of protein, as this may indicate that it contains phenylalanine.

Phenylalanine is an amino acid that is found in many drinks, such as tea, coffee, soft drinks and juice. It also occurs naturally in some foods such as almonds. In the human brain it is a precursor for the neurotransmitters dopamine and norepinephrine.

The article talks about the use of Phenylalanine in drinks and how it affects the production of neurotransmitters – dopamine and norepinephrine – which are responsible for feelings of pleasure and happiness. Without these two neurotransmitters one can become stressed or anxious. The article further elaborates on how a lack of these two neurotransmitters can lead to depression.

Phenylalanine in Coke

Phenylalanine is found in many kinds of drinks. It can be found in milk, soy milk, fruit juice, and sodas.

Phenylalanine is an essential amino acid that is needed for growth and development. It can also help protect against mental decline later in life, which makes it an important amino acid to consume throughout the day.

Phenylalanine in Gum

Phenylalanine is a natural amino acid that can be found in gum.

It is best to avoid chewing gums with this amino acid as it can have side effects on the human body. In some cases, an overdose can lead to seizures and mental disorders.

Phenylalanine is an amino acid that is present in many different types of food, most notably in cheese and soy beans. This article will explore the role of phenylalanine in gum.

Phenylalanine is an amino acid that can be found in foods like cheese and soybeans. As it is not an essential amino acid, the body can produce it on its own with carbohydrate intake. It can also be found in gum, where it acts as a sweetener to make the taste more appealing.

5HTP (5-Hydroxytryptophan also known as Oxitriptan) is an amino acid that is produced naturally by the body. 5HTP is made from amino acid tryptophan that is derived from food items. 5-HTP is the primary precursor to serotonin. It is also an Nootropic and nutritional supplement, 5-HTP is a favorite among people who believe in its efficacy in the treatment of depression. In addition, it is used to treat other serotonin-related illnesses. However, using 5-HTP to treat anxiety and depression isn’t scientifically supported.

This research contradicts the way 5-HTP is perceived by manypeople, including medical professionals. If we look into the studies, we discover that 5-HTP could be contraindicated for those suffering from depression. marketers recommend the use of. We’re all about increasing the neurotransmitter levels and enhancing the performance of our brains here on National Lab Day. However, every now and then we come across an dietary or nootropic supplement that is gaining popularity. However, it could also be an especially dangerous idea. We’ll explore the way 5-HTP functions in the brain with this article. We’ll discuss why it’s crucial to brain health. There are many reasons to be looking for a different way to increase the levels of serotonin within your brain. 5-HTP can help:

• Anxiety & Depression. 5-HTP is converted into serotonin within brain cells. Serotonin levels that are elevated can ease the symptoms of depression and anxiety.
• Neurotransmitters. 5HTP is an essential ingredient in serotonin synthesizing, which improves social and mood, enhances memory and regulates appetite, digestion and sleep. It also regulates sexual desire, sleep and functions.
• Brain Optimization. A balanced balance of the neurotransmitters serotonin and dopamine are essential to ensure that the brain is highly efficient. If these neurotransmitters aren’t in equilibrium, it can affect mood and memory cognitive function, decision-making sexual desire, and many other vital essential functions of life.

5-HTP Supplement Overview

5-HTP (5-Hydroxytryptophan or oxitriptan) is an amino acid made from the amino acid tryptophan.  5-HTP Tryptophan is hydroxylated by tryptophan hydroxylase to 5-HTP (5-hydroxytryptophan), then decarboxylated to serotonin (5-hydroxytryptamine or 5-HT).

Tryptophan 5-HTP Serotonin

80-90 percent of the serotonin in your body is produced by the intestines of your body. However, serotonin isn’t able to traverse through the brain-blood barrier. Therefore, all the serotonin your brain requires must be produced in the brain. This is the place where 5-HTP is found… 5-HTP traverses the blood-brain barrier more quickly that tryptophan. It is synthesized to serotonin in a much faster manner than the tryptophan.

As an neurotransmitter serotonin affects both indirectly and directly most brain cells. If you’re looking to increase serotonin levels within your brain many find that taking 5-HTP supplements is superior to taking tryptophan. Tryptophan is the ingredient that your body makes to create 5-HTP is found in chicken, turkey milk, potatoes, sunflower seeds, pumpkin turnip, collard and turnip greens as well as seaweed. 5-HTP as an Nootropic supplement is an amino acid that is derived from the seed pods from Griffonia simplicifolia that are located throughout West as well as Central Africa. The 5-HTP levels in the extracts of the plant range between 2 and 20.83 percent (from seeds sourced from Ghana).

What does 5-HTP do?

5-HTP is an precursor to serotonin. The neurotransmitter serotonin is involved in appetite, sleep and memory, as well as mood, learning and sexual function. If tryptophan’s function in converting into 5-HTP to boost serotonin isn’t working effectively and the result is usually anxiety, chronic headaches and insomnia. A trial with an open label was carried out in Italy to test the effectiveness of 5-HTP treatment in children with excessive levels of “romantic anxiety”. Serotonin is linked to human romantic attraction. Researchers in this study sought to measure the brain’s levels in brain-derived

Neurotrophic Factor (BDNF) and serotonin in connection to changes in stress levels during the course of the study. Healthy participants (mean of 23.3 years) who experienced an ” romantic breakup” participated in the study. Participants were given 60 mg of Griffonia simplicifolia, a plant extract that contained 12.8 mg of 5-HTP every day for six weeks. The subjects were screened for the BDNF as well as serotonin level prior to the start of the study, after 3 weeks , and again after the six-week study. The researchers observed significant improvement in the scores of romantic stress from the weeks of 0 to 3.

The 5-HTP appears to work. However, no improvements were observed from the weeks 3 to six. Even though the younger people were significantly more deficient in BDNF as well as serotonin.

5-HTP Depression

The ” romantic breakup” study is an excellent illustration of how the use of 5-HTP as a treatment for stress and depression may not be effective. If it does however, it’s not likely to last long.  Depression can be more than just serotonin deficiency.

Depression may also be linked with catecholamine imbalance, such as dopamine or norepinephrine. or a mixture with serotonin and catecholamine dysfunction. If you consume 5-HTP on its own it also depletes dopamine, norepinephrine and the hormone epinephrine. The synthesis of serotonin by 5-HTP and dopamine from L-DOPA is facilitated through the enzyme the L-aromatic amino acid decarboxylase (AAAD). Serotonin precursor and dopamine supplementation should be used in a proper proportion. Since when you only use 5-HTP, it is the dominant chemical on level AAAD. AAAD enzyme synthesizing level.

The blockage of dopamine synthesis in the AAAD enzyme by inhibiting competitive activity can result in the depletion of dopamine as well as the other catecholamines. Looking back to the Italian study of teenagers who were suffering from “romantic stress” The subjects stopped responding to 5-HTP during the 2 2nd portion of our study. Most likely because their catecholamine levels decreased due to the continuous use of 5-HTP. Research has shown that once dopamine levels are low enough the 5-HTP receptor ceases to perform its function.

5-HTP Supplement for Depression

If the levels of catecholamine neurotransmitters (dopamine or norepinephrine) affect the mood, adding 5-HTP by itself is not the best method to take. Since you could reduce the levels of dopamine and norepinephrine increasing the severity of the condition and its root cause. However, this contraindication isn’t only confined to depression. It is applicable to all illnesses in which catecholamine dysfunction is implicated. This includes ADHD and anxiety, obesity as well as seasonal affective disorder. Parkinson’s Disease.

Serotonin is a precursor of amino acids. (i.e. 5HTP) as well as dopamine (i.e. L-Tyrosine) collaborate during the process of synthesis, metabolism, and transport until they function as one unit. If dopamine and serotonin are in a balanced state and functioning properly, those functions that are controlled only by serotonin can be controlled by manipulating the levels of dopamine.

Functions that are controlled only by dopamine in this equilibrium state are regulated through manipulation of the levels of serotonin. If you disturb this balance and don’t properly add serotonin or dopamine precursors, you won’t achieve the desired effects of this Nootropic. You also increase the risk of adverse negative effects. If you supplement your diet with just the one of your precursors (i.e. 5-HTP to increase serotonin) which dominates another system (i.e. dopamine synthesizing) and it is likely that depletion of the dominant system will take place (i.e. depleted dopamine). If this effect is too strong that you don’t receive the benefits you were seeking when you supplement with the precursor that was originally used (i.e. 5-HTP).

An excellent example of this effect can be seen in the treatment of Parkinson’s Disease where the effects of L-DOPA have been seen over time because of the depletion of serotonin. Serotonin and dopamine are unable to traverse through the brain-blood barrier The amount of dopamine and serotonin molecules within the brain is dependent on the quantity of nutrients (amino acid precursors) that can be converted into neurotransmitter molecules. Enhancing the brain’s function while minimizing side negative effects is not a result of taking supplements until you have sufficient levels of amino acids. It’s about getting the right balance between dopamine and serotonin.

5-HTP Benefits

5-HTP is essential for the synthesizing serotonin in your brain. However, supplementing 5-HTP with 5-HTP to increase serotonin levels is not working effectively. The use of 5-HTP for treating depression has not had much results in the past few decades of biohacking and clinical trials. Incorporating 5HTP in the Nootropics stack is a lot more complex than just adding 5-HTP to increase serotonin levels. 5-HTP by itself is not effective for depression, or for any other problem you’re facing that involves catecholamines (dopamine and norepinephrine as well as epinephrine) due to 5-HTP’s ability to reduce these neurotransmitters. 5-HTP can increase serotonin levels in your brain. However, 5-HTP should be carefully placed in conjunction with precursors to dopamine and norepinephrine, or you could make the situation even worse. It is best to be careful not to supplement with just one of the dopamine or serotonin amino acid precursors. If amino acid precursors aren’t in equilibrium, you will end having a lower effectiveness of this nootropic, more adverse effects as well as loss of the dominant system.

5-HTP Dosage for Anxiety

The reactions to the supplementation with 5-HTP can vary but one thing that is consistent is the initial feeling of well-being more sleep, less requirement to sleep, better mood and less social anxiety. less appetite, a better capacity to handle stress, and better cognitive functioning.

After a few weeks of taking 5-HTP, adverse effects start to manifest. Serotonin overdose causes the depletion of dopamine and norepinephrine. The side effects can include depressive, sluggishness, brain nausea, brain fog, and headaches. The worst case scenario could be nausea, vomiting, and possibly being blacked out. Neurohackers who have had consistently good results with supplementation using 5-HTP, stack it with B-Vitamins which is a dopamine precursor similar to NALT and use only 5-HTP when it is needed. People who have had a negative experience with 5-HTP right from the beginning often don’t know the reason they’ve experienced a negative reaction. But an educated guess is their depression was catecholamine (dopamine, norepinephrine, epinephrine)-related. Serotonin boosting caused their dopamine-related problems to get worse.

5-HTP Withdrawal

Don’t use 5-HTP in conjunction with or with antidepressant medicine. You are in real risk from Serotonin syndrome that could eventually kill you.

5-HTP Dosage

Supplements with 5-HTP are widely advertised as a natural cure for depression. However, the research doesn’t support the use of 5-HTP to treat depression. There are many years of clinical trials to choose from. There is no proof of the effectiveness of using 5-HTP to treat depression. The Department of Public Health at the University of Queensland Medical School in Australia conducted a systematic review of the literature from 1966 to 2000 on “5-HTP” as well as “depression”. Researchers discovered 108 studies in clinical trials of which just two studies, one involving serotonin (5-HT) and the other with L-Tryptophan, for a total of 64 patients, met the requirements for quality to be considered. The research suggests serotonin (5-HT) as well as L-Tryptophan may be more effective than placebo in reducing depression. But the researchers noted “the small size of the studies, and the large number of inadmissible, poorly executed studies, cast doubt on the results from potential publication bias, and suggests that they are insufficiently evaluated to assess their effectiveness.”

5-HTP Fibromyalgia

A double-blind, placebo-controlled study in Italy examined the effectiveness of 5-HTP for treating the symptoms of fibromyalgia. 50 patients suffering from primary fibromyalgia syndrome were chosen to participate in this study. The study from 1990 did not release the dosage of 5-HTP taken. However, the researchers observed an improvement in the symptoms of fibromyalgia, with only minor and temporary adverse negative effects.

5-HTP Reviews

Insufficient neurotransmitter activity serotonin and norepinephrine is the central component of the depression model that is widely believed by neurobiologists of today. In the late 1970’s and early 1980’s, a variety of studies were conducted in which patients suffering from depression were treated with the serotonin precursors, L-Tryptophan and 5-Hydroxytryptophan (5-HTP) as well as the precursors to norepinephrine and dopamine Tyrosine and L-Phenylalanine.. A report published within the Alternative Medicine Revue looked at the results of all these studies. The author pointed out the fact that the nature these research makes the process difficult for drawing solid conclusions about the effectiveness of neurotransmitter precursors to treat depression. There is evidence to suggest that the loading of precursors could be effective, especially for serotonin precursor 5-HTP further studies with a suitable size and design “might result in more definitive results”. The studies haven’t materialized since the report was released sixteen years ago.

5-HTP Dosage for Anxiety

The recommended dosage for 5-HTP if you’re planning to test the product is fifty mg one three times per each day.  Certain studies have utilized higher doses than the recommended dosage, however 5-HTP is toxic in very high doses. For depression or anxiety For depression or anxiety, 5-HTP should be dosed between 150 and 300 mg daily. To relieve post MDMA (Ecstasy) depression, 5-HTP 100 mg on Day 3-7 after MDMA use.

Alpha GPC (L-Alpha Glycerylphosphorylcholine, choline alfoscerate) is a choline source derived from soy or sunflower lecithin. It’s also found naturally in tiny amounts within the body.

Alpha GPC is more bioavailable than other sources of choline to provide brain health benefits. Contrary to choline citrate and choline bitartrate, it is able to cross the blood brain barrier. This is what makes Alpha GPC a preferred choline source for experts Nootropic users.

Alpha GPC is a precursor to the neurotransmitter acetylcholine, which is essential.

Alpha GPC helps:

• Brain Energy. Alpha GPC improves mood, and increases mental energy. The added choline may increase the clarity and alertness of your thoughts.
• Neurotransmitters. Alpha GPC is prized for its capacity to boost memory. Its bioavailability is high, which is a fantastic source of choline to produce the neurotransmitter Acetylcholine.
• Brain Optimization. Alpha GPC boosts the development of new brain cells. It also enhances the brain’s capacity in repairing damaged membranes of cells.

Alpha GPC Uses: Overview

Alpha GPC is a kind of choline produced in tiny amounts within your body. It can also be gotten by eating organ meats, wheat germ and dairy products.

Choline is regarded as to be an important nutrient since the body utilizes it more quickly than it could create it, you require additional choline, either through food or as a supplement.

Choline is required to produce the neurotransmitter Acetylcholine. It also helps to make the phosphatidylcholine (PC), used to build cell membranes.

Alpha GPC Sleep

Choline is so essential in cognitive function as well as neuron function that, without it, we wouldn’t be able to be able to think, move, sleep , or even remember anything.

Alpha-GPC Growth Hormone

Alpha GPC is a component of the body. It also aids in the production of the human growth hormone. Athletes utilize it to boost their performance and also to build muscles. It boosts energy levels for training and faster recuperation. [i]

We’ll discuss the way Alpha GPC affects your brain health and the chemistry.

Alpha GPC vs. CDP-Choline Vs. Choline Bitartrate: What’s the difference?

Choline is a nutrient that is water-soluble and its composition is comparable with Vitamin B. Alpha GPC, CDP-Choline, Choline Citrate and Choline Bitartrate are all the sources of choline.

CDP-Choline (cytidine 5′-diphosphocholine): Is only about 18% choline by weight. The body naturally synthesizes choline to form the CDP-Choline (Citicoline). Then it is converted into the phosphatidylcholine (PC) that helps cell membranes and aids in the creation of Acetylcholine.

Choline Bitartrate

A low-cost type of choline that is approximately 40% choline by weight. Thus, 1 Gram of Choline Bitartrate offers 400 mg of Choline. It isn’t able to traverse the blood-brain barrier. Therefore, you won’t get the same amount of nootropic benefits like Alpha GPC or CDP-Choline.

Alpha GPC approximately 40% choline in weight and is able to cross the blood brain barrier. Alpha GPC is naturally present in the brain as a byproduct of the phosphatidylcholine (PC). If your brain requires more choline and the choline in your brain is low It is broken down PC in cell membranes. It also transforms the PC into Alpha GPC.

The brain and body love it when you utilize Alpha GPC. Since it doesn’t need to eat the cells of its own to gain more Choline.

What is Alpha GPC Work in the Brain?

Alpha GPC boosts brain health and function in a variety of ways. Two of them are notable.

1. Alpha GPC boosts acetylcholine which is a neurotransmitter linked to memory and overall brain function. Alpha GPC is a precursor to Acetylcholine. Enhancing the effectiveness of communication among neurons within your brain. The increase in neural signals improves memory and learning, cognitive processing and mental clarity.

A study conducted in one of the centers, where 32 healthy participants were given one of two options: the Alpha GPC or placebo in an initial treatment. After 10 days, they were given the drug scopolamine to cause amnesia. Researchers found Alpha GPC was able to stop the loss of memory and attention typically caused by the scopolamine. [ii]

The researchers found the memory functions in healthy young people can be improved to a level. It is as easy as using Alpha GPC as a supplement.

2. Alpha GPC directly impacts development of cell membranes within the cerebral cortex. The outer layer of neural tissue, also known as ” gray matter” is the center of information processing in your brain. It regulates motor function and organization, as well as personality making plans and even the ability to touch. [iii]

In the journal Clinical Therapeutics Researchers conducted a double-blind placebo-controlled study with people with mild or moderate dementia. 400 mg capsules were given three times a every day over a period of 180 days. The results of this study revealed a steady improvement in the condition of dementia patients who received Alpha GPC. [ivIV

What happens when things go wrong

As we age the brain’s chemical chemistry and metabolism of energy changes.

• Recall, reaction time and mood decrease
• Brain cell membranes degenerate
• Acetylcholine levels decline[v]
• The growth factor for nerves within the brain decreases.

All of these changes associated with aging contribute to neurodegenerative illnesses of aging which include Alzheimer’s disease and dementia.

Even if you’re not worried about the effects of ageing, Alpha GPC can help.

Alpha GPC benefits

Studies from hundreds of studies has shown the following: Alpha GPC will:

• Enhance memory and improve learning abilities [viImprove memory and learning ability [vi
• Improve the bioavailability Acetylcholine [vii].
• Restore and increase the number of the growth of nerve receptors in the brain [viiiRestore and boost nerve growth factor receptors in the brain [viii
• Growth hormones are a major contributor to growth across all age groups [ixIncrease growth hormones in all age groups [ix
• Enhance cognitive performance and improve memory in patients with Alzheimer’s disease [xx

Alpha GPC is water-soluble and rapidly enters your brain once you have taken it. Once inside your brain, it improves signal transmission and also protects neurons.

Alpha GPC improves your brain functioning and learning process by directly increasing the synthesis and release of Acetylcholine. Your body is calling to it.

This type of choline does not function as a precursor for the phosphatidylcholine (PC) however it is an an metabolite that PC uses. This means that once PC is broken down and removed from its fat acids, the only thing left are Alpha GPC.

Instead of searching the brain’s membranes to find Alpha GPC, you give it precisely the kind of choline it’s looking for.

What does Alpha GPC feel?

If you are having trouble getting up in the morning, consider coffee with 400 mg of Alpha GPC. Instead of the usual high sugar breakfast, a high carbohydrate one.

Alpha GPC can be a excellent way to increase your energy. It is best to take it for 45 minutes prior to you exercise.

Alpha GPC helps with memory, mental performance, mood and energy. Its brain-supporting properties and capacity to provide acetylcholine fuel to the brain cells will improve cognitive abilities in all ages and gender categories.

Alpha GPC Clinical Research

Researchers in one research study demonstrated the fact that Alpha GPC had positive effects in boosting the human growth hormone. [xiThe study also showed that Alpha GPC had positive effects on human growth hormone.

Alpha GPC Dopamine

Another study demonstrated an rise in the production of dopamine. [xiiDopamine is a neurotransmitter that can be released. This is especially important in demonstrating Alpha GPC can help those who suffer from dopamine deficiency. and alleviating symptoms of depressive disorder as well as Parkinson’s Disease.

Alpha GPC Facilitates Learning and Memory

A current study demonstrates Alpha GPC improving memory and focus. This research shows Alpha GPC increasing the effectiveness of pairing it with donepezil (acetylcholinesterase inhibitor).

Much better than taking donepezil by itself.

In rats, Alpha GPC boosted learning and memory. It boosted brain energy processes and reduced structural changes caused by age in the cerebral cortex. [xiii] [xiv[xiv]

Alpha GPC Alzheimer’s

Thirteen clinical trials have been published that involved the totality of 4,054 Alzheimer’s patients, consistently demonstrated Alpha GPC: [xvThe Alpha GPC was found to be [xv

• Increased attention and memory
• Improved recovery for stroke patients
• The symptoms that are associated with acute cerebrovascular disease.
• It is far more efficient than using choline or lecithin to treat disease

Alpha GPC Dose

Alpha GPC is approximately 40% choline in weight. Thus, 1000 mg Alpha GPC provides approximately 400 mg of Choline.

• Alpha GPC suggested dosage for cognitive benefits is between 400 and 1,200 mg daily.
• The recommended dosage for athletic training Alpha GPC is 400 mg early in the morning. Then, another dose of 400 mg 15 to 30 minutes prior to exercising.
• Treatment for clinical conditions of Alzheimer’s Disease, dementia and other cognitive disorders. The dosage is up to 1,200 mg daily.

For greater doses, divide your daily Alpha GPC total into 2 or 3 doses daily. For instance 1,200 mg could be taken at 400 mg at one period of.

Alpha-GPC Side Effects

Alpha GPC is produced naturally within the body. It is therefore considered to be well-tolerated and secure.

The effects of the drug are not common but may include headaches, fatigue nausea, nervousness, diarrhea and digestive issues. It is usually a sign that there is excessive levels of choline in your body.

Since Alpha GPC causes an energy increase in many neurohackers, be sure to avoid taking Alpha GPC at night. You may also have trouble sleeping.

Alpha GPC Withdrawal

The effects of Alpha GPC withdrawals on the brain can be devastating. It can cause a person to have a negative mood, difficulty concentrating on tasks, and difficulty speaking.

Alpha GPC is a natural supplement that is used to reduce or prevent muscle spasms in people with multiple sclerosis and other neurological diseases. In some cases it may be prescribed for seizures, Alzheimer’s disease, attention deficit hyperactivity disorder (ADHD), and dementia.

The effects of Alpha GPC withdrawal are dependent on the dose being taken before discontinuing supplementation or intake. People who are taking doses of 500mg or less will notice significant withdrawal symptoms within 72 hours after discontinuing the supplement.

Type of Alpha GPC to buy

Since Alpha GPC tends to liquefy between 99 and 100 percent, several suppliers offer 50 percent Alpha GPC powder combined with 50 percent of fillers like silicon dioxide. Adjust your dosage accordingly.

Alpha GPC is made from sunflower lecithin or soy. If you’re trying to eliminate soy from your diet, search for Alpha GPC that is “no soy” or labeled as being derived by sunflower lecithin.

Alpha GPC 400 – 1,200 mg per day

Lithium is an alkali that is soft and silvery-white metal that is so reactive (it sparkles when it comes in contact with water) that it isn’t found in the natural world. Instead it’s found in mineral compounds as well as in mineral water.

Cosmologists believe in lithium was one of the three elements synthesized during the Big Bang. It’s been there for a while.

We often think of lithium as a treatment for mental disorders such as bipolar disorder and manic depression. The lithium-ion battery inside our phones. It is known to explode at times.

It turns out that the anti-psychotic drug lithium isn’t a drug at all. It’s actually an mineral. It’s part of the group of minerals which include sodium as well as sodium.

As a nootropic, micro-dosing lithium provides some amazing anti-aging benefits. Recent research suggests that low dose lithium can also slow the progress of neurodegenerative diseases such as Alzheimer’s, dementia , and Parkinson’s disease.

The low-dose lithium also aids the process of neurogenesis as well as memory. It also helps in regulating mood.

We’ll look at the regular or daily use of Lithium Orotate as an nootropic and how it can benefit cognition health.

Lithium assists in:

• The balance of mood. Lithium can reduce the mania (extreme extremes of highs or lows) through reducing the sensitivity of the norepinephrine post-synaptic receptor. It also increases the uptake of norepinephrine in synaptosomes. It prevents the release of this chemical transmitter. Lithium enhances the transfer of Vitamin B12 and folate into brain cells. It affects the mood and aggression.
• Growth Factors. Lithium increases the levels of brain-derived neurotrophic factors (BDNF) as well as neurogrowth factor (NGF) neurotrophin-3 (NT3) and their receptors. Additionally, lithium increases the number of stem cells in the brain. All of which are responsible for boosting the neurogenesis and aiding in the healing process from any type of brain injuries.
• Neuroprotection. Lithium boosts brain gray matter, enhances DNA replication in neurogenesis, stops apoptosis, enhances N-acetyl aspartate (NAA) and reduces beta-amyloid production and guards against injury once it is formed. It also chelates aluminum and shields against glutamate-induced toxicity.

Lithium Orotate Uses: Overview

Lithium is an alkali mineral , and is one of the trace elements that are vital for both human and animal reproductive health as well as general wellness and health.

It was discovered as a chemical element in 1817, the first documented medical usage was in 1871, for the treatment of mania.

However, the use for lithium to treat ailments dates way back to Greek as well as Roman times. People would soak into the alkali springs to treat mental and physical ailments.

Mineral springs to treat ailments since the beginning of time.

Springs located in Douglas County, Georgia was so well-known that people traveled for miles to take a sip of the water.

The Sweet Water hotel, a luxurious 500-room hotel, was inaugurated in 1887. It attracted famous authors as well as businessmen and prominent politicians who came to enjoy the health benefits of the spring. Lithia is the name ” Lithia” originates from the lithium-rich water..

Research from all over all over the world have demonstrated the health advantages from the mineral lithium. A study based on information from 27 Texas counties between 1978 and 1987 revealed that the levels for murder, suicide, and the rape rate were higher for counties where drinking water had little or none lithium.

Another study on the lithium concentrations in water from taps from 18 cities in Japan revealed the standard mortality rates lower in areas that had higher levels of lithium.

Another study that was conducted by researchers in Texas during 2013 has confirmed findings of the first study in the state. Water samples taken from 226 counties revealed an relationship between the levels of lithium as well as suicide rate.

Researchers who carried out meta-analyses of the lithium levels and public drinking water have suggested ” increasing lithium levels in drinking water may lower the risk of suicide and also justify the addition of lithium in drinking water from the tap.”

A piece published in The Lancet published in the year 1949 published by John Cade is credited for the use of modern medicine for lithium as a successful treatment for manic psychosis.

The United States FDA approved high doses of lithium carbonate and lithium citrate in the year 1970 for the treatment of bipolar disorder. Carbonic acid and citric acid are minerals that transport lithium throughout your body.

Doctors may also recommend lithium off-label to treat seizures, migraines, and psychosis, usually when other treatments have been unsuccessful.

However, as we dig into the latest research regarding lithium and lithium, we see that the importance of this element vital to ensure the brain’s health and function.

It is believed that the lithium that we obtain from our diets can help prevent many mental and neurological disorders. Micro-dosing lithium for an nootropic using a supplement such as Lithium Orotate could aid in making up things we can’t get from food and water.

Lithium is found naturally in processed meat, fish dairy products, milk eggs, potatoes, and other vegetables. The typical daily consumption from lithium could range between 2 and 600 mg. The amount varies based on the location the food is produced.

Lithium Orotate Benefits

Lithium aids in the brain’s function and health in a variety of ways. Two of them are notable.

1. Lithium improves mood. Recent studies have revealed the fact that lithium’s effects on mood stability could result from its capacity to increase the production of new neurons in the brain (neurogenesis).

Lithium blocks the enzyme glycogen synthase Kinase-3b (GSK-3b). This inhibition increases the brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) which stimulates neural stem cells to create new neurons within the hippocampus.

The moment neural stem cells create new neurons within the hippocampus and affect the mood as well as memory function as intended. However, a failure of neurogenesis causes mood disorders.

Lithium has been used for a long time to reduce the symptoms of mania and to stabilize moods for bipolar sufferers. However, it is not commonly considered to be an antidepressant. Researchers from Tel Aviv provided the first evidence that blocking GSK-3b resulted in an quick antidepressant effect on mouse.

Another group at the Howard Hughes Medical Institute in Pennsylvania demonstrated the feeding of mice with chow with low dose lithium for 15 days resulted in an dosing-dependent effect on antidepressants.

Lithium stimulated genes in amygdala, hippocampus as well as the hypothalamus. The entire brain is implicated in depression anxiety, bipolar disorder as well as the autism spectrum and schizophrenia..

2. Lithium is a brain protector. The brain cells are constantly at danger of being damaged due to the toxins that you come across daily from water, air, food and the environment. The excitotoxins created by normal metabolism of brain cells.

Glutamate plays an important role in synaptic plasticity that is required to learn and memory. However, excessive activity of glutamate’s NMDA receptors triggers neuron death , which is linked to Alzheimer’s Parkinson’s, Huntington’s and other forms of. Lithium blocks this overactivity.

The lithium also boosts levels of neuroprotective proteins known as BCL-2. Researchers believe the fact that lithium may be the sole “medication” which has proven to boost bcl-2 levels in a variety of brain regions.

Lithium is also being studied in the prevention and treatment of traumatizing brain injuries. In a research study that was conducted in 2014 the researcher the researcher Dr. Peter Leeds stated that lithium had “demonstrated significant beneficial effects in the laboratory models of TBI.” (TBI). This includes a decrease in brain lesions caused by TBI and neuroinflammation suppression and protection from blood-brain barrier disruption and normalization of behavioral impairments and improvements in memory and learning and memory, among others.”

In 1985 the year 1985, in 1985, the United States EPA determined that the consumption of lithium from food items in the USA varied between 0.6 to 3.1 mg/day. To compare, those living within the Andes in Northern Argentina consume 2 to 30 mg a day and 2 to 3 mg in drinking waters.

When your intake of salt as well as caffeine intake increases as will the excretion of lithium in your urine, which raises the need for this vital trace mineral.

Stress and toxins from substances such as mercury, aspartame MSG, Bisphenol A (BPA) and other excitotoxins also increase cortisol levels and various stress-related hormones. This increases your need for water-soluble nutrients , such as B-vitamins zinc, magnesium and lithium.

Low levels of lithium levels are linked to …

• Depression and anxiety increase
• Memory and learning capacity decrease
• Insomnia increases
• Sensitivity to stress and chronic pain increases
• Natural healing processes decline

A regular consumption of lithium can help to prevent many neurological and mental illnesses because of its trace mineral impacts on the metabolism of the nervous system. It also has antioxidant and anti-inflammatory effects.

Lithium’s benefits

The research and clinical studies regarding the neuroprotective properties from lithium are overwhelming that some scientists are starting to wonder ” why isn’t everyone taking lithium“?

Here’s a brief overview of the ways that micro-dosing lithium with lithium Orotate will benefit the brain.

• Blocks the process of apoptosis The molecule lithium blocks GSK-3 that has been associated with the death of cells that are apoptotic.
• NMDA-receptors – Lithium reduces the toxicity of glutamate that is caused by NMDA receptors, which aids in the treatment of mood disorders, Alzheimer’s and various other autoimmune and inflammatory disorders.
• Neuroprotection Blocks the growth of plaque and beta-amyloid tangles
• Neurogenesis – Lithium promotes the BDNF required for synaptic plasticity in memory and learning. Lithium also increases the growth of nerves as well as the glial-derived neurotrophic factor that affects mood, memory, learning and general health of the brain.
• Stem cells of the neuron stem cells of the brain lithium stimulates the stem cells required to create the new neuron (neurogenesis)
• stabilizes the mood Stabilizes mood lithium is known to provide an uplifting effect for healthy individuals as well as those suffering from bipolar disorder, depression, and mania.
• Prevention of suicide sufficient levels of lithium have been proven to decrease the risk of suicide in numerous studies conducted around the world.
• Depression Depression lithium aids in treating resistant depression. In actual fact, lithium has been proven to increase the efficacy of antidepressant drugs.
• N-acetyl Aspartate (NAA) – lithium boosts NAA, which has been linked to higher scores in IQ (i.e. lithium can make you more intelligent!)

Benefits of supplementing your diet with lithium extend beyond improving your cognitive health. Lithium can also help reduce insulin resistance, aids in the treating alcoholism and other addictions, helps support bone health, regulates the cycle of circadian and much more.

Lithium Orotate Anxiety / ADHD / Sleep and More

Some people report feeling the effects after taking a small dosage of lithium rapidly. However, for certain people individuals, the full effects could take anywhere from one to three weeks. Micro-dosing 5-10 milligrams of lithium every day will yield consistent results in a month or two months for certain. I’ve seen amazing results in just only a few days.

If you’re prone to lash out at people with anger and aren’t sure the reason you’re so angry It could be because the fact that your lithium levels are low.

A lot of neurohackers suffering from anxiety and depression notice changes rapidly. Within the first few days, you will feel more relaxed, calm, and feel less stressed..

Be aware the fact that lithium in any form isn’t for everyone. If you’re able to get enough lithium through your water and diet, but still have the mood swings discussed in this article it is possible that you are having other issues. It is possible to determine within a few hours after taking low-dose lithium whether this is the right supplement suitable for you.

For certain people, Lithium Orotate is feeling elated over life, for the very first time in a long while. Stress as well as anxieties about social interaction have become less of a concern. It is now more enjoyable and relaxing.

Some believe that Lithium Orotate is more effective than any other medication has ever been tried to treat depression that is severe. It offers a pleasant and smooth mood balance, without the toxicity that comes with massive doses in lithium carbonate.

If you’re suffering from the symptoms of PTSD or even mild insomnia, you might want to consider the Lithium Orotate. Concentration may increase, racing thoughts lessen and motivation levels may rise. You’ll be able to have greater ability to cope.

Acetyl-L Carnitine (ALCAR ALC, LAC or) is a synthesized form of L-Carnitine. It is a derivative of the amino acids Lysine as well as methionine..

ALCAR can be more bioavailable than L-Carnitine. It is able to cross through the brain-blood barrier. It also delivers L-Carnitine through cell membranes (which it wouldn’t be capable of crossing by itself).

L-Carnitine is a natural substance that is produced by your kidneys and liver. It is then transferred to other tissues, including your heart and brain.

ALCAR assists:

• Brain Energy Metabolism. ALCAR assists in the transport of fat acids into mitochondria which are required to regulate energy metabolism. The fueling of your cells “power plants” can increase mental and physical energy.
• Neurotransmitters. ALCAR is an essential component of the process of acetylcholine creation. It improves the memory of people, their mental alertness, and fluid thinking.
• Brain Optimization. The antioxidant properties of Acetyl-L Carnitine enhance neuroprotection, and boost the brain-derived Neurotrophic Factor (BDNF), and improves the circulation of cerebral blood.

Acetyl-L-Carnitine Overview

The amino acid L-Carnitine that’s produced by your body. It is also found in dairy products and red meat.

L-Carnitine is regarded as to be a “conditionally vital” nutrient due to the fact that your body utilizes it more than it is able to produce it, you require supplemental L-Carnitine, either through food or as a supplement.

L-Carnitine is utilized throughout the body. We’re talking about L-Carnitine in the Acetyl-L Carnitine version of L-Carnitine due to its effects on the brain’s health and chemical chemistry.

L-Carnitine vs Acetyl-L-Carnitine: What’s the difference?

Acetyl-L-Carnitine and L-Carnitine are commonly called Carnitine. However, they are structurally distinct and have their own advantages.

L-Carnitine provides energy to mitochondria in your cells, but it is not able to cross the blood brain barrier. L-Carnitine supplements are difficult to be absorbed by your body and only 18% of it gets into your bloodstream.

L-Carnitine is popular with those who are athletes or dieters looking for the benefits of fat metabolism. However, they aren’t looking for any benefits for the brain.

Acetyl-L-Carnitine is more easily absorbed and utilized by the body than L-Carnitine. A study found that taking 2 grams of it daily for 50 days increased ALCAR levels in blood by 43 percent.

ALCAR is able to do everything L-Carnitine can, but it does also penetrate the blood-brain barrier. In a different study, researchers discovered that ALCAR helps protect the brain’s cells against oxidative stress, unlike L-Carnitine, which does not.

What is the function of Acetyl-L-Carnitine within the brain?

Acetyl-L-Carnitine improves brain health and function in a variety of ways. Two of them are notable.

1. ALCAR boosts acetylcholine, a neurotransmitter tied to memory and overall brain function.Acetyl-L-Carnitine is a precursor to acetylcholine in the presence of Coenzyme-A. ALCAR provides an “methyl compound” to create Acetylcholine.

Alzheimer’s diseased brains have an increase of 25% to 40% decrease in carnitine Acetyltransferase, an enzyme in the brain that functions in conjunction with the L-Carnitine & Acetyl-L-Carnitine.

The decline in brain enzymes has led to researchers identifying the low ALCAR with low Acetylcholine and the onset of Alzheimer’s disease. They then suggested ALCAR as a possible treatment to help the brain regenerate.

2. ALCAR helps to increase the brain’s energy by supplying the mitochondria in your brain cells.

ALCAR acts as an organelle for transporting the fatty acids across cell membranes. Directly to the cell’s power plant mitochondria.

• As ALCAR moves fat acids through mitochondria, it creates the fuel needed to burn to generate energy.
• As ALCAR moves fat acids through mitochondria and flushes harmful byproducts.

ALCAR keeps mitochondria functioning in almost every cell in your body. The brain uses about 20 percent of the energy you use. It also produces a variety of harmful byproducts. Therefore, ALCAR is a must to ensure the health of your brain.

As we age the brain’s chemical and energy metabolism change.

• Nerve growth factor in the brain decreases
• Acetyl-L-Carnitine levels decline
• Acetylcholine levels decline
• Mitochondria loses efficiency

All of these changes associated with aging contribute to neurodegenerative illnesses of aging, such as dementia and Alzheimer’s.

Acetyl-L-Carnitine Benefits

The research conducted by the Linus Pauling Institute at Oregon State University has shown that Acetyl-L-Carnitine can:

• Restore mitochondrial energy production in a sustainable way.
• Restore mitochondrial structure
• Restore ALCAR and acetylcholine levels in the body and brain

ALCAR’s have the capability to increase acetylcholine levels and regenerate the brain’s cells (including mitochondria). It has been demonstrated to be beneficial for people suffering from dementia-related brain disorders such as Major depression and Alzheimer’s.

A study on animals that was conducted at New Delhi showed that Acetyl L-Carnitine decreases lipofuscin levels in the brain’s cortex and hippocampus, the thalamus and striatum.

What does Acetyl-L-Carnitine do?

It is possible to not be feeling the ALCAR… If you’re old or suffer from Erectile Dysfunction. Within these specific categories, Acetyl-L-Carnitine aids in mood, memory mental performance, and the ability to maintain and get an erection.

The brain-supporting properties of ALCAR and ability to power mitochondria in the brain cells will improve cognition across all ages and gender categories.

Acetyl-L-Carnitine Reviews

ALCAR is a nootropic. ALCAR reviews of users report an increase in energy and speed of thinking.

Researchers in one research study demonstrated that ALCAR could be able to have beneficial effects on dementia and depression.

Another study was conducted in Italy Researchers found Acetyl-L-Carnitine stimulated the development of neurites. The more of these tiny projections of nerve cells resulted in an increase in the signaling among cells in the nervous system central (brain and the spinal cord)

A study carried out by the Mount Sinai School of Medicine in New York found that ALCAR could be a viable treatment for signs associated with Parkinson’s Disease. Through directly affecting mitochondrial respiration, and supporting dopamine neurons, and the usage for dopamine within the brain.

ALCAR can help those suffering from Mild Cognitive Impairment (MCI)

A gold-standard double-blind, random controlled study of 1,204 participants demonstrated a significant impact on mental performance, attention memory, and other cognitive functions.

In this study, ALCAR was found to prevent the further deterioration of the brain. It could also be considered a treatment for degeneration of the brain.

Acetyl-L-Carnitine slows the rate in cognitive decline

130 patients with Alzheimer’s disease were treated with ALCAR or placebo every day for a whole year. They were tested on 14 cognitive points.

The study showed a less rapid decline in cognitive performance for the ALCAR group as compared to those in the placebo.

ALCAR is effective for chronic fatigue syndrome

Acetyl-L-Carnitine is known to reduce the fatigue of patients suffering from chronic fatigue syndrome.

In a double-blind, randomized crossover study, 36 patients were treated for three months using or amantadine (used to treat Chronic Fatigue), or 1 gram of ALCAR twice every day.

The study’s results revealed that ALCAR was more well-tolerated and was more effective than medication to treat tiredness.

Acetyl-L-Carnitine helps protect against the oxidative effects of Ecstasy (MDMA)

Research has proven ALCAR to be efficient in defending mitochondria from the effects of oxidative stress. However, these researchers went one step higher.

Male rats were treated with Acetyl-L-Carnitine prior to a dose of Ecstasy (MDMA). ALCAR treatment “exerts an effective protection against the neurotoxicity induced by MDMA on the level of mitochondria” according to the research team.

ALCAR for Erectile Dysfunction?

The study involved 120 participants were divided into three groups. The first group was given the equivalent of 160 mg testosterone each day. The 2^nd group was given 2 grams of Propionyl-L-Carnitine plus 2 grams of Acetyl-L-Carnitine per day. The 3 ^3rd group was given a placebo.

Did you know that exists an International Index of Erectile Function?

Turns out the Propionyl-L-Carnitine/Acetyl-L-Carnitine stack was better than testosterone for erectile dysfunction. It is free of the negative side effects associated with an overly large prostate, it gives better gasps, greater sexual desire, and better mental state.

Acetyl-L-Carnitine Dosage

• The recommended dosage of Acetyl-L-Carnitine for cognitive benefits is 1 to 4 grams daily.
• To improve mood and get rid of fatigue chronic, take 1 3 – three grams ALCAR daily. day.
• For memory issues related to age For memory issues related to age, take 1 – two grams ALCAR daily. day.

ALCAR is water-soluble and may be consumed on an empty stomach by drinking water. Some supplement companies recommend taking their Acetyl-L-Carnitine during meals. This implies that it’s fat-soluble, but I’ve not found any evidence in the literature of science.

Acetyl-L-Carnitine Side Effects

Acetyl-L-Carnitine is a natural substance produced by the body. It is therefore considered to be well-tolerated and secure.

The effects of side effects are not common, but may include nausea, vomiting and agitation.

Acetyl L-Carnitine Weight Loss

Other ALCAR side effects include the loss of weight, and restlessness.

There is also an increase in the frequency of seizures when you suffer from any type seizures disorder.

Types of ALCAR to buy

• Acetyl-L-Carnitine L-Carnitine that has an additional acetyl group. This form is more bioavailable and is able to cross the blood brain barrier.
• L-Carnitine It is the most common form of carnitine that is found in food.
• Lipo-Carn ^(r) A unique blend of Acetyl-L-Carnitine and Alpha-Lipoic Acid. Research has proven that this combination to be a potent anti-aging combination.Together, they help fight diabetes, increase energy production, and maintain cognitive function, and protects the body from chemical and radiation toxic substances and boosts to boost immunity.
• Propionyl-L-Carnitine: L-Carnitine combined with propionic acid. This type of supplement is noted for its antioxidant properties and is utilized to improve heart health. It is also beneficial for erectile dysfunction.
• Biosint(tm) is a pharmaceutical grade Acetyl-L-Carnitine which is produced by Sigma Tau HealthSciences in Italy through Sigma Tau HealthSciences

DMAE (Dimethylaminoethanol, Deanol, Deaner) has two methyl groups and is structurally similar to choline, which is a direct precursor to the synthesis of acetylcholine (ACh).

ACh is a crucial neurotransmitter that affects all aspects of life from memories to control of muscles. It is the connection that ACh is in to DMAE that drives the majority of the buzz surrounding the use of DMAE as an effective Nootropic.

However, it is evident it is true that DMAE is not an ingredient that is precursor to Acetylcholine as stated on a variety of websites for brain-optimization and nootropics. Many neurohackers have reported that supplementing their diet with the DMAE has been a huge help to their brains.

We’ll attempt to clarify some confusion as well as false information regarding the use of DMAE as a nootropic ingredient. If you’re looking to add the DMAE in the stack is logical, then it’s worth it.

DMAE assists:

• Neuroprotection. DMAE assists in eliminating the lipofuscin as well as free radicals from brain cells.
• Neurotransmitters. DMAE blocks the choline absorption by cells, thereby allowing more free Choline to enter your system. Additionally, DMAE increases the cholinergic receptors which can increase the utilization of Acetylcholine (ACh) in your brain.
• Mood. DMAE supplementation can improve mood and energy, while also influencing sleep patterns.

What is DMAE used for?

DMAE (Dimethylaminoethanol, Deanol, Deaner) is an amine naturally produced in small amounts in your brain. The high levels of DMAE can also be found in fish such as anchovies and Sardines.

Researchers have suggested the possibility that DMAE could boost the acetylcholine (ACh) levels in the brain through inhibiting the choline metabolic activity in the peripheral tissue.

By blocking the utilization of choline in other tissues (including the synthesis process into Acetylcholine), DMAE increases choline levels in the bloodstream.

When DMAE passes through over the brain-blood barrier it boosts the choline levels within the brain. Therefore, with higher levels of choline levels, you are likely to see higher levels of Acetylcholine (ACh).

However, research has revealed that this isn’t always what happens when the DMAE is introduced to the brain. In one study, the DMAE was quickly absorbed to the brain. However, when it reached synapses there was no change. Choline levels increased, however, they did not transform into Acetylcholine.

What’s the issue what’s going on here? We must first examine the process by which Acetylcholine (ACh) is made. ACh is produced in a single-step reaction that is catalyzed by the enzyme Choline Acetyltransferase (ChAT). The most efficient steps in ACh synthesizing are that choline is available as well as Acetyl coenzyme A (Acetyl-CoA).

The only other source of acetylcholine (ACh) is synthetization from phosphatidylcholine (PC) via phosphatidylethanolamine N-methyltransferase (PEMT). And this ACh synthesis only happens in cholinergic receptors.

It appears it is the case that DMAE is not able to be converted into either the choline as well as ACh. The only method by which that DMAE increases the amount of choline is through blocking the metabolism of choline.

The reason the levels of choline increase in the brain after supplementation by the DMAE is due to the fact that choline is unable to make itself into Acetylcholine (ACh).

Why is it that certain neurohackers see a difference in improved focus, clarity of thinking as well as an antidepressant effect from the DMAE?

It is possible that DMAE triggers the cholinergic receptors to begin taking action. With more choline in the system due to DMAE the neuroreceptors could decide to create an extra ACh.

DMAE could be beneficial to people who suffer from the deficiency in choline within the brain. Studies have shown the the DMAE efficiency in brain is dependent on how healthy the system of cholinergic nerves within the brain.

As neurohackers, we are able to make more effective choices to boost the acetylcholine within the brain. Centrophenoxine which is a combination of DMAE and cCPA (parachlorphenoxyacetic acid) seems to boost acetylcholine in the brain much more efficiently than DMAE.

What is the DMAE Function within the brain?

DMAE improves brain health and function in a variety of ways. Two of them are notable.

1. The DMAE compound is neuroprotector. Lipofuscin can be described as an cellular waste product that builds up within brain cells when we get older. It’s the same waste material that creates brown spots on the skin. Lipofuscin is found within your body’s cells including your eyes, brain the kidneys, liver the heart, adrenal glands, as well as nerve cell (neurons).

Neurohackers frequently report the fact that their supplementation by DMAE results in enhanced perception. This effect on vision could be due to the result of DMAE’s capability to remove the waste products like the lipofuscin out of cells which can affect vision.

The is the lipofuscin removal mechanism that is triggered through the DMAE has been demonstrated through animal research. Researchers employed centrophenoxine injections in 17-month-old female mice. The mice were injected every day for three months.

Researchers studied the changes that occur in pigment layers in the retinas in both the eyes in the mice. They found significant reduction in the pigment lipofuscin in the animals treated.

Centrophenoxine is broken down to DMAE when it is inside your body. It is DMA within this nootropic that gives you the the lipofuscin scavenger effects.

2. DMAE improves the mood and attention. DMAE has been proven by neurohackers to enhance the quality of attention, vigilance and well-being as well as energy as well as reducing depressive symptoms.. A study conducted by German researchers could explain how the feeling of wellbeing comes from supplementing DMAE..

The double-blind placebo-controlled study included 80 subjects from the human population equally split between male and female. The study examined the brain’s electrical response when they were shown five videos lasting 7 minutes, with a three-minute pause for each.

The same procedure was carried out after six and twelve weeks of daily consumption in the form of the drug or a placebo. Subjects who took DMAE for three months showed substantially lower than theta as well as Alpha brainwaves.

The decrease in theta and alpha brain waves have been linked to an increase in alertness and focus. Subjects who used DMAE also were less active, and felt more relaxed..

Researchers concluded that DMAE could create a better sense of well-being.

As we age the brain’s chemical chemistry and metabolism of energy changes.

• Concentration, working memory and executive function decline
• Cholinergic receptors degenerate
• DMAE levels decline
• Lipofuscin and free radicals accumulate in brain cells.

All of these changes due to age can be affected by the decline in DMAE amounts. They are also contributing to neurodegenerative disorders as well as depressive disorders..

The DMAE levels are a natural result of ageing. They can also contribute to the development of degenerative diseases.

DMAE benefits

DMAE boosts the levels of choline in the brain. This rise in the levels of choline and DMAE’s capacity to trigger cholinergic receptors into actions could result in the increase of the acetylcholine (ACh) levels.

However, the molecule DMAE is not able to directly increase the acetylcholine concentrations in brain. The DMAE hormone is not an precursor to Acetylcholine. [xi]

The increased levels of ACh levels impact the memory and learning process. ACh aids in with the encode of memories as well as your capacity to focus. As neurohackers, we definitely would like to boost the acetylcholine levels. Particularly if our brains are deficient in ACh.

However, DMAE isn’t the most effective method to reach the desired goal of achieving elevated ACh level.

The research into the effects of DMAE is ongoing, and there could be some advantages from the DMAE supplementation that are not yet recognized by the neurohacking community or research group. [xii]

DMAE is utilized to treat a range of disorders ranging that range from cognitive disorders to ADHD. DMAE can also be found in products for skin care to reduce the appearance of wrinkles, age spots and wrinkles, as well as wrinkles and sagging the skin. [xiii]

Free radicals can cause harm to DNA, disrupt the metabolism of cells, and trigger the production of oxygen species which kill brain cells.[xivA few studies have discovered that DMAE is a fairly efficient free radical scavenger.[xv[xv]

DMAE has been proven to reduce the amount in “cross-linking” in proteins associated with diseases such as Alzheimer’s.[xviResearchers believe that this could be due to the effectiveness of DMAE as a free radical scavenger.[xvii[xvii]

The DMAE is believed to cause dreams that are lucid. [xviii]

DMAE Dopamine: Does it boost it?

Certain neurohackers have reported they have noticed that the DMAE supplementation can cause a significant increase in their ability to focus.

DMA users frequently have the following reports:

• improved memory (especially short-term memory)
• Mentally alert
• improved focus
• mental clarity
• better sleeping patterns

Injecting higher doses of than DMAE than is recommended is believed to cause you feel anxious and stressed. You may also experience muscle spasms, especially in your neck and shoulders.

DMAE Nootropic

Early DMAE Research

The prescription version of DMAE, known as Deaner also known as Deanol was used in clinical trials from the 1960’s and 1970’s. Deanol was prescribed to treat behavioral and learning issues that are that were caused by a decreased attention span.

Two clinical studies conducted more than 40 years ago that proved the effectiveness of DMAE to treat what’s today called ADHD are listed below.

However, in 1983 in 1983, the FDA in all their wisdom demanded additional studies to confirm the efficacy of DMAE. Because clinical trials were more expensive than the sales of products could afford the manufacturer, the company that made Deanol and Deaner removed them from the market.

DMAE can now be purchased as a supplement. A supplement which your psychiatrist or doctor will probably not prescribe to you to treat your ADHD.

DMAE to Treat ADHD

A double-blind, placebo-controlled research evaluated the effect on the brain of DMAE supplementation with the drug methylphenidate (Ritalin) to treat ADHD. Children diagnosed with learning difficulties and hyperactivity were referred to the study.

The children were given 40 milligrams of Ritalin 500 mg of DMAE as well as a placebo every day for three months. Reaction times, behavior as well as other tests for psychometrics were conducted prior to and following treatment.

Both of the ‘drugs’ were found to be effective in various tests. Researchers concluded that the supplementation of DMAE significantly enhanced performance for children suffering from behavior and learning problems.

Another study by Dr. Carl Pfeiffer of the Brain-Bio Center located in Princeton, New Jersey with 25 girls and 83 boys showed similar results when the use of DMAE to treat ADHD.

In this study the researcher Dr. Pfeiffer discovered that DMAE improved the behavior of 2/3 of males and 3/4 of the girls. Attention span improved as was hyperactivity and irritability. reduced, and scholastic performance increased and in some instances even IQ was boosted.

Also, If you’re ADHD and taking Ritalin as well as Adderall and are looking for a natural alternative you might want to consider DMAE.

DMAE use in Cosmetics

The majority of research conducted on the DMAE during the 1950’s and 1960’s was centered on the use of this compound to improve the brain’s health and cognitive function.

Recent research into the DMAE compound is mostly focused on the use of the ingredient in formulations for cosmetics for the skin.

DMAE has been proven to improve skin firmness, even in the midst of a young skin. A study of 30 healthy adults between the ages of 36 to 49, applied the DMAE gel or a placebo. The study’s results revealed that the skin treated with DMAE was more firm.

Another study that was randomized utilized 33 percent DMAE face gel applied every day over a period of 16 weeks. The gel helped reduce wrinkles and lines in the area of eyes and enhance the shape of the lips as well as fullness. Additionally, the results were not diminished even two weeks after discontinuing use.

A second open-label extension to the same study showed that the long-term use to DMAE gel was safe and had an excellent security profil.

DMAE Dosage

Dosage recommended for DMAE is between 100 and 200 mg daily.

DMAE nootropic supplements are typically advertised as bitartrate DMAE. One capsule of bitartrate DMAE is just 37 percent of DMAE and the remainder is 67 percent tartaric acid.

The 250 mg dose of bitartrate DMAE gives 92.5 mg of real DMAE..

You should take the dose of DMAE dose in the morning , either before or after breakfast. Take DMAE several times per each week however, not all day long.

DMAE Bitartrate Dosage

If you plan to take DMAE, make sure you combine it with a reliable source of Choline. Be aware that DMAE can inhibit the metabolism of choline as well as the choline. You absolutely require the choline as well as Acetylcholine to have a well-functioning brain.

DMAE inhibits phospholipid synthesis. This means that you won’t receive any help from the choline precursors. It is essential to find a reliable source of Choline.

Without going into an extensive explanation of the mechanism of the process Phosphatidylcholine (PC) as well as Omega-3’s and CDP-Choline can aid in repairing the harm that is caused from long-term DMAE usage.

DMAE Side Effects

DMA is considered to be non-toxic and suitable for short-term or intermittent usage. The body naturally produces DMAE by itself.

There shouldn’t be any adverse negative effects as long as you make use of the DMAE in the recommended dosages.

Certain neurohackers experience headaches, insomnia and tension in the muscles. Most often, it’s due to the dose being excessive.

If you experience an adverse reaction to DMAE, discontinue using DMAE immediately..

If you’re planning on getting pregnant, do not take the DMAE. Studies have proven that DMAE can hinder the development of the baby’s cerebral.

If you suffer from epilepsy or bipolar disorder, it is best to avoid DMAE completely.

Check out “DMAE Dosage Notes” on the best way you can combine DMAE in the event that you decide to add this nootropic.

Is DMAE Banned?

The ingredients in DMAE can help increase the production of acetylcholine. Acetylcholine is a neurotransmitter that stimulates muscles and other nerves, increases blood flow, and increases mental alertness.

DMAE is not banned as it’s been proven to be safe for human consumption.

DMAE is not banned. It is just that some people were using it as a weight loss supplement and there were no clinical studies to back this claim up.

DMAE is found in many skin creams and anti-wrinkle products because it helps with muscle contraction, but it is not a magic cure for wrinkles or weight loss. DMAE has been shown to be effective at reducing wrinkles but only when a person also follows a healthy diet and exercise regimen.

DMAE is not banned. It is FDA approved and not considered dangerous according to the FDA.

DMAE, or dimethylaminoethanol, has been used for many purposes over the years, but it has the most documented use as a topical treatment for wrinkles and age spots.

The FDA does not consider DMAE to be dangerous if it is used in accordance with approved labeling.

DMAE has been banned by specific countries but that does not mean that it is banned all around the world.

Where to buy DMAE

The DMAE is available as capsules, tablets powder, liquid Gels, creams and tablets.

DMAE capsules and tablets typically bitartrate DMAE (see ” Dosage Notes”) and 150-350 mg.

Based on the dimensions of the capsule or tablet, make the conversion to pure DMAE based on the size of the capsule or tablet Start slowly by taking a small dose of 50 mg. See how you react.